Sonographic predicting factors of latency interval in pregnancies complicated by preterm premature rupture of membranes

Authors

  • Ioannis Tsakiridis
  • Aikaterini Apostolopoulou
  • Efstathios Papaeftstathiou
  • Menelaos Kyriakakis
  • Ioannis Kalogiannidis
  • Apostolos Mamopoulos
  • Themistoklis Dagklis
  • Apostolos Athanasiadis

Keywords:

preterm prelabor rupture of membranes, cervical length, ultrasound, amniotic fluid, prediction

Abstract

Objectives: Preterm prelabor rupture of membranes (PPROM) is associated with significant perinatal morbidity and mortality. To date, the latency period to delivery cannot be reliably predicted. The aim of this study was to identify potential sonographic predictors of the interval until delivery in cases with PPROM.

Methods: This was a retrospective cohort study of all singleton pregnancies with PPROM between 24+0 and 33+6 gestational weeks that were admitted in the 3rd Academic Department of Obstetrics and Gynecology Department of the Aristotle University of Thessaloniki between January 2016 and December 2019. Sonographic parameters including the cervical length (CL) and the deepest vertical pool (DVP) of amniotic fluid, as well as the pregnancy outcomes were examined.

Results: In total, 50 women fulfilled the inclusion criteria and were included in the study. The multivariate analysis (multiple linear regression) revealed that only the CL made a unique contribution (p=0.001, beta=0.542) to the latency interval. Moreover, in the subgroup multivariate analyses (binary logistic regression), only the CL correlated significantly with a latency interval greater than 2 days (p=0.008, OR=1.142, 95% CI=1.036-1.262) or latency>7 days (p=0.034, OR=1.076, 95% CI=1.005-1.125).

Conclusions: The CL may be an independent predictor for the latency interval in pregnancies with PPROM between 24 and 34 gestational weeks. Further research is needed on potential sonographic and other biomarkers for the effective prediction of imminent delivery.

Author Biographies

Ioannis Tsakiridis

3rd Department of Obstetrics and Gynaecology, School of Medicine, Aristotle University of Thessaloniki, Greece

Aikaterini Apostolopoulou

Laboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Aristotle University of Thessaloniki, Greece

Efstathios Papaeftstathiou

2nd Department of Urology, School of Medicine, Aristotle University of Thessaloniki, Greece

Menelaos Kyriakakis

3rd Department of Obstetrics and Gynaecology, School of Medicine, Aristotle University of Thessaloniki, Greece

Ioannis Kalogiannidis

3rd Department of Obstetrics and Gynaecology, School of Medicine, Aristotle University of Thessaloniki, Greece

Apostolos Mamopoulos

3rd Department of Obstetrics and Gynaecology, School of Medicine, Aristotle University of Thessaloniki, Greece

Themistoklis Dagklis

3rd Department of Obstetrics and Gynaecology, School of Medicine, Aristotle University of Thessaloniki, Greece

Apostolos Athanasiadis

3rd Department of Obstetrics and Gynaecology, School of Medicine, Aristotle University of Thessaloniki, Greece

Downloads

Published

2021-07-13